Buy Phentermine Online

Buy Phentermine Online DESCRIPTION Phentermine (hydrochloride) is a sympathomimetic amine with pharmacological activity similar to that of amphetamine. Drugs of this class that are used in obesity are commonly known as "anorectics" or "anorectics". It has not been established that the action of these drugs in the treatment of obesity is mainly the suppression of appetite. Other actions on the central nervous system may be involved, or metabolic effects, for example, stimulation of the central nervous system and elevation of blood pressure. Phentermine hydrochloride is indicated in the treatment of exogenous obesity as short-term (some weeks) adjunct in a regimen of weight reduction based on caloric restriction. Obese adults instructed in diet management and treated with "anorexigenic" drugs lose more weight on average than those treated with placebo and diet. The magnitude of weight loss of patients treated with the drug compared with patients treated with placebo is only a fraction of a kilo per week. The rate of weight loss is greater in the first weeks of treatment, and tends to decrease in the following weeks. The natural history of obesity is measured in years, whereas studies with phenformin are limited to a duration of a few weeks; Therefore, the total impact of weight loss induced by the drug on the diet alone should be considered clinically limited. Mechanism of action: all centrally acting anorexigenic drugs are derivatives of phenylethylamine. The structure of phenylethylamine is also the basis of neurotransmitters; Dopamine, noradrenaline (NE) and adrenaline (monoamines). Phentermine stimulates the release of NE from the nerve endings, increasing the amount of NE that interacts with the postsynaptic receptors. The binding sites of these substances in the hypothalamus are regulated through ion channels by the glucose level, stimulating the Na + / K + ATPase pump. In animal studies, all phenylethylamine derivatives have been shown to reduce hunger. Pharmacokinetics: After oral administration of 15 mg of phenformin, the maximum plasma concentrations of 49.1 ng / mL are reached at 6 hours. The area under the AUC curve is 2000 ng * h / mL. Phentermine binds by 17.5% to plasma proteins. The apparent volume of distribution is 348L. Phentermine is metabolized by p-hydroxylation of the aromatic ring and by N-oxidation of the aliphatic side chain. The CYP 3A4 isoenzyme of cytochrome P450 is involved in the metabolism of phentermine although it does not appear to be too active. INDICATIONS AND DOSAGE Treatment of exogenous obesity in conjunction with diet: Oral administration Adults: 30 mg (one capsule) in approximately 2 hours after breakfast for appetite control. Medication should be avoided late in the evening because of the potential for insomnia. Administration of 30 mg daily is adequate for appetite depression of twelve to fourteen hours. Children: Phentermine is not recommended for children under 12 years of age. CONTRAINDICATIONS AND PRECAUTIONS Phentermine is contraindicated in patients with hypersensitivity or idiosyncrasy to sympathomimetic amines. It is also contraindicated in advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, and glaucoma. Because of its potential to cause addiction, phentermine is contraindicated in arousal states, patients with a history of drug abuse, during or within 14 days following the administration of monoamine oxidase inhibitors, due to the danger of hypertensive crises. Tolerance to the anorexic effect usually develops within a few weeks. When this occurs, the recommended dose should not be exceeded in an attempt to increase the effect; Rather, the drug should be discontinued. Phentermine is chemically and pharmacologically related to amphetamines. Amphetamines and other related stimulants have been widely abused, and the possibility of phentermine abuse should be taken into account when evaluating the desirability of including this drug in a weight reduction program. Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction. There are reports of patients who have increased the dose to many times the recommended dose. Abrupt discontinuation after administration of high and prolonged doses results in extreme fatigue and mental depression; There are also changes in the sleep EEG. The manifestations of chronic intoxication with anorexigenic drugs include severe dermatosis, marked insomnia, irritability, hyperactivity and personality changes. The most serious manifestation of chronic poisoning is psychosis, often clinically indistinguishable from schizophrenia. The safe use of phentermine in pregnancy has not been established. The use of phentermine by women who are or who may become pregnant, and those in the first trimester of pregnancy, requires that the potential benefit against the potential danger to the mother and child be weighed. INTERACTIONS Phentermine can cause serious side effects if it is given with: duloxetine Monoamine Oxidase Inhibitors (MAOIs) pseudoephedrine or phenylephrine procarbazine sibutramine SSRIs, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline stimulants, such as dexmethylphenidate, methylphenidate or modafinil venlafaxine ADVERSE REACTIONS The main adverse reactions produced by phentermine are: Cardiovascular system: palpitations, tachycardia, elevated blood pressure. Nervous nervous system: overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache; Psychotic episodes rarely in the recommended doses. Gastrointestinal system: Dry mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disorders. Immune system: Urticaria. Endocrine system: impotence, changes in libido. The manifestations of acute phentermine overdose include restlessness, tremors, hyperreflexia, rapid breathing, confusion, aggression, hallucinations, and panic states. Fatigue and depression often follow central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal intoxication usually ends in seizures and coma. Management of acute intoxication by phentermine is mainly symptomatic and includes lavage and sedation with barbiturates. Experience with hemodialysis or peritoneal dialysis is insufficient to allow recommendations in this regard. Acidification of the urine increases the excretion of phentermine. Intravenous phentolamine has been suggested as a possible treatment of acute hypertension if this complicates phentermine overdose. PRESENTATIONS ADIPEX, caps 30 mg ACXION, caps 30 mg